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The most active phase, the ethyl acetate extract of Gentiana striata Maxim. EGS , displayed potent inhibitory activity on feet oedema of rheumatoid arthritis RA inflicted rats.
This anti-inflammatory activity might be partly based on the notable reduction of prostaglandin E2 PGE2 and nitric oxide NO levels.
Six further compounds isolated from EGS have previously been reported as having anti-inflammatory activity. Keywords: Gentiana striata Maxim. Introduction Gentiana, containing about species, is the largest genus in the family Gentianaceae Struwe et al. Plants belonging to Gentiana are widely used in traditional medicines in many countries. Among them, Gentiana Macrophylla Radix. Gentiana striata Maxim. However, there is no previous work reporting the pharmacological activities and chemical constituents of G.
Preliminary studies indicate that the ethyl acetate extract of G. EGS is the most active phase when compared with petroleum spirit and aqueous extracts of G. Moreover, RA is a chronic systemic inFammatory disease associated with long-term disability and premature mortality. Many medicines are clinically prescribed for treating this hard-to-cure illness. Prednisone is a common anti-inFammatory medicine and is generally used for treating RA.
In this study, we assess the anti-inFammatory activity of EGS on RA on feet oedema of rats, which were compared with those of prednisone. We further investigated its chemical constituents, finding that six compounds, i. Email: lichong lzu. Cao et al. Chemical structures of isolated compounds from EGS. Figure 2. Results and discussion 2.
Paw volume and body weight Figure 2 a displayed the changes in the paw volume values following EGS treatment. By sharp contrast, prednisone dramatically reduced the body weight. These data suggested that EGS produced a potent anti-inflammatory effect without significant impact on body weight. Although prednisone also reduced the NO concentration in serum, its effect was much weaker than that by EGS. These data suggested that the anti-inflammatory action of EGS might be correlated with the inhibition of endogenous NO synthesis.
Natural Product Research 3 Table 1.
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